Her Royal Highness Princess Reema bint Bandar bin Sultan bin Abdulaziz Al Saud was appointed Ambassador to the United States on February 23, 2019 by the Custodian of the Two Holy Mosques King Salman bin Abdulaziz. She is the first woman in the country’s history to serve in the role of Ambassador. She presented her credentials to President Donald Trump on July 8, 2019.

In 2000, She co-founded Yibreen, a women’s gym and spa. From 2007 until 2015, Princess Reema was the Chief Executive Officer of Alfa International Company Limited - Harvey Nichols Riyadh, a multi-brand luxury retail company, where she collaborated with leading female recruitment agency, Glowork, and commissioned a study on Obstacles for Women in the Workplace, which set the tone for female inclusion in retail, and resulted in opening the first workplace nursery in a retail store, enabling more women to work while caring for children.

Reema is a member of The World Bank's advisory council for the Women Entrepreneurs Finance Initiative. In 2016, Princess Reema left the private sector to begin a career of public service as Vice President of Women’s Affairs at the Saudi General Sports Authority where she developed policies and programs that benefited women and children throughout Saudi Arabia. After a successful year, she was promoted to Deputy of Development and Planning in January 2018.

In 2017, Reema was awarded Sheikh Mohammed bin Rashid Al Maktoum Creative Sport Award in its ninth edition for her role played in the empowerment of women in the region through her spirit of entrepreneurship and philanthropy.

In October 2018, she was also appointed President of the Mass Participation Federation, making her the first woman to lead a multi-sports federation in the Kingdom, a role that she occupied until her appointment as Saudi Ambassador to the United States. Reema bint Bandar's tenure as Ambassador has been marked by several notable achievements. She has worked to promote women's rights in Saudi Arabia and has been a vocal advocate for greater gender equality in the country. She has also been a strong supporter of Saudi Arabia's Vision 2030 plan, which aims to diversify the country's economy and reduce its dependence on oil.

As part of her philanthropic work, Princess Reema became a founding member of the Zahra Breast Cancer Awareness Association in 2007, which set a Guinness World Record by forming the World's Largest Human Awareness Ribbon at the Princess Noura University in Riyadh in 2015.

Princess Reema has served as a member of the World Bank’s advisory council for the Women Entrepreneurs Finance Initiative since 2017. She has been a member of the Saudi Arabian Olympic Committee since 2017, and a member of the International Olympic Committee (IOC) Women in Sports Commission since 2018.

In 2014, Fast Company recognized Princess Reema as the Most Creative Person of the year for “Inviting Women into the Workforce.” Foreign Policy Magazine recognized her as a Leading Global Thinker for the same year, placing her high up in the “Moguls” category. She was featured on the Forbes lists of the 200 Most Powerful Arab Women and Most Powerful Arab Women in Saudi Arabia lists for 2014. In 2013, she founded Alf Khair, a social enterprise aimed at elevating the professional capital of Saudi women through a curriculum developed to enable financial self-sufficiency.

In 2021, she founded "Catmosphere Foundation" to support Panthera Corporation's work to preserve big cats. On 6 November 2021, the first awareness campaign "Catwalk" took place, a walkathon in several countries.

Reema bint Bandar has remained steadfast in her commitment to promoting Saudi Arabia's interests and advancing the cause of women's rights in the country. Her leadership and vision have inspired many young women in Saudi Arabia and around the world to pursue their dreams and make a positive impact in their lives.